Publications

Independent Research

1.     Śmiłowicz, D.; Schlyer, D.; Boros, E.; Meimetis, L. "Evaluation of a RadioIMmunostimulant (RIMS) in a syngeneic model of murine prostate cancer and immunoPET analysis of T-Cell distribution." Molecular Pharmaceutics. 2022, 19 (9), 3217-3227.

Mentored Research: Harvard/MGH, UBC, SFU

1.     Li, Y.; Daryaee, F.; Yoon, G.E.; Noh, D.; Smith-Jones, P.M.; Si, Y.; Walker, S.G.; Turkman, N.; Meimetis, L.; Tonge, P.J. "Positron emission tomography imaging of staphylococcus aureus infection using a nitro-prodrug analogue of 2-[18F]F-p-aminobenzoic acid." ACS Infectious Diseases. 2020, 6(8), 2249-2259 (PMID: 32672928).

2.     Dubach, J.M.; Eunha. K.; Yang, K.; Cuccarese, M.; Giedt, R.J.; Meimetis, L.G.; Vinegoni, C.; Weissleder, R. “Quantitating drug-target engagement in single cells in vitro and in vivo.” Nature Chemical Biology. 2016, 13(2), 168-173.

3.     Meimetis, L.G.; Giedt, R.J.; Mikula, H.; Carlson, J.C.; Kohler, R.; Pirovich, D.B.; Weissleder, R. “Fluorescent vinblastine probes for live cell imaging.” Chemical Communications. 2016, 52(64), 9953-9956.

4.     Aquda, A.H.; Lavallee, V.; Cheng, P.; Bott, T.M.; Meimetis, L.G.; Law, S.; Nguyen, N.T.; Williams, D.E.; Kaleta, J.; Davies, J.; Villanueva, I.; Andersen, R.J.; Brayer, G.D.; Bromme, D. “Affinity crystallography: A new approach to extracting high affinity protease inhibitors from natural extracts.” Journal of Natural Products. 2016, 79(8), 1962-1970.

5.     Meimetis, L.G.; Boros, E.; Carlson, J.C.; Ran, C.; Caravan, P.; Weissleder, R. “Bioorthogonal fluorophore linked DFO-Technology enabling facile chelator quantification and multimodal imaging of antibodies.” Bioconjugate Chemistry. 2016, 27(1), 257-263.

6.     Abazari, A.; Meimetis, L.G.; Budin, G.; Bale, S.S.; Weissleder, R.; Toner, M. “Engineered trehalose permeable to mammalian cells.” PLos One. 2015, 10(6), e0130323.

7.     Banuelos, C.A.; Lal, A.; Tien, A.H.; Shah, N.; Yang, Y.C.; Mawji, N.R.; Meimetis, L.G.; Park, J.; Kunzhong, J.; Andersen, R.J.; Sadar, M.D. “Characterization of Niphatenones that inhibit androgen receptor N-terminal domain.” PLos One. 2014, 9(9), e107991/1-e107991/10, 10 pp.

8.     Meimetis, L.G.; Carlson, C.T.; Giedt, R.J.; Kohler, R.H.; Weissleder, R. “Ultrafluorogenic coumarin-tetrazine probes for real-time biological imaging.” Angewandte Chemie International Edition. 2014, 53(29), 7531-7534.

9.  Carlson, C.T*.; Meimetis, L.G*.; Hildebrand, S.A.; Weissleder, R. “BODIPY-Tetrazine derivatives as superbright bioorthogonal turn-on probes.” Angewandte Chemie International Edition. 2013, 52(27), 6917-6920.

10.  Yang, Y.C.; Meimetis, L.G.; Tien, A.H.; Mawji, N.R.; Carr, G.; Wang, J.; Andersen, R.J.; Sadar, M.D. “Spongian diterpenoids inhibit androgen receptor activity” Molecular Cancer Therapeutics. 2013, 52(27), 6917-6920.

11.  Meimetis, L.G.; Nodwell, M.; Yang, L.; Wang, X.; Wu, J.; Harwig, C.; Stenton, G.R.; Mackenzie, L.F.; MacRury, T.; Patrick, B.O.; Ming-Lum, A.; Ong,C.J.; Krystal, G.; Mui, A.L.-F.; Andersen, R.J. "Synthesis of SHIP1 activating analogues of the sponge meroterpenoid Pelorol." European Journal of Organic Chemistry. 2012(27), 5195-5207.

12.  Meimetis, L.G.; Williams, D.E.; Mawji, N.R.; Banuelos, C.A.; Lal, A.A.; Park, J.J.; Tien, A.H.; Fernandez, J.G; de Voogdt, N.J.; Sadar, M.D.; Andersen, R.J. “Niphatenones, glycerol ethers from the sponge Niphates Digitalis block androgen receptor transcriptional activity in prostate cancer cells: Structure Elucidation, Synthesis, and Biological Activity.” Journal of Medicinal Chemistry. 2012, 55(1), 503-514.

13.  Cho, I.; Meimetis, L.G.; Belding, L.; Katz, M.J.; Dudding, T.; Britton, R. “Directed ortho,ortho'-dimetalation of hydrobenzoin: Rapid access to hydrobenzoin derivatives useful for asymmetric synthesis.” Beilstein Journal of Organic Chemistry. 2011, 7, 1315-1322.

14.  Cho I.; Meimetis, L.G.; Britton R. “Bidirectional metalation of hydrobenzoin: direct access to new chiral ligands and auxiliaries.” Organic Letters. 2009, 11(9), 1903-1906.

Patents

1.     Meimetis, L.; Boros, E. “Immunostimulant-cytotoxic conjugate composition and methods for cancer treatment”, (Filed, 2022).

2. Meimetis, L.; Rothstein, J.; Bell, K.; Carriere, C.; Molloy, M.; Kuta, A.; Schwertner, N.; Day, M.; Huang, X.; Pechenick, D.; Kline, T. “Anti-human VISTA antibodies and antibody-antiinflammatory drug conjugates for targeted delivery and/or for alleviating the toxicity of anti-inflammatory agents such as steroids”, WO2021216913.

3. Meimetis, L.; Tonge, P. J.; Li, Y.; Daryaee, F.; Smith-Jones, P. M. “Positron imaging tomography imaging agent composition and method for detection of bacterial infection”, WO2021226076.

4. Meimetis, L. “Preparation of 1-[4-(aminomethyl)benzyl]-2-butyl-2H-pyrazolo[3,4-c]quinolin-4-amine derivatives and related compounds as TLR-7/TLR-8 agonists and their antibody conjugates containing a dipeptidyl linker for use in cancer therapy and diagnosis”, WO2020257235A1.

5. Meimetis, L.G.; Carlson, J.; Weissleder, R. “Bioorthogonal turn-on probes”, US20160121002A1.

6. Meimetis, L.G.; Nodwell, M.B.; Wang, X.; Andersen, R.J. “Ship1 modulators and related methods”, US9000050B2.